If you visit a particular website often and if you’d like to create a keyboard shortcut to open it in your browser, do the following:

Open Internet Explorer 8. Click on Favorites and right click a favorite website, whose keyboard shortcut, you want to create. Select Properties.
Now in the Properties box > Web Document tab, place your cursor in the Shortcut key panel.
Click the preferred shortcut key/s (say Ctrl+F2) on your keyboard. These will get displayed in the panel.
Click Apply > OK.
Now click the keys Ctrl+F2, and you will find your browser opening the website.
