Why is Manual Malware Cleaning necessary, when you already have anti-virus solutions available?
Watch this video on Advanced Manual Malware Cleaning Techniques by Mark Russinovich.
One needs to be prepared to identify, analyze & remediate malware that slips through layered defenses since most anti-malware solutions depend on signatures of KNOWN threats.
This video takes you on a tour of malware infection & persistence technologies, including rootkits & shows you on real malware infections how to use sophisticated freeware tools from SysInternals like Process Explorer, Autoruns & Rootkit Revealer to clean malware manually.
Watch video at Microsoft TechNet.