Microsoft WebMatrix makes it easy for anyone to create a WordPress site. WordPress available from the Web Application Gallery is fully tested to run on WebMatrix. Using Webmatrix, you can customize your site easily and then publish it on the internet from a wide choice of hosting service providers.
WordPress is one of the most popular open-source blogging, publishing and content management systems, with a deep plugin and theme architecture that allows for limitless possibilities.
WordPress also runs great on the Microsoft Web Platform. Microsoft has teamed up with the WordPress Community to make using WordPress on Windows even easier and Microsoft along with its hosting partners is working to make hosting WordPress on Windows a great choice for everyone.
The Microsoft Web Platform Installer will download any pre-requisites and then install WebMatrix and WordPress for you.
Detailed technical information, tutorials, links and resources for installing and tuning WordPress using WebMatrix is available here.